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Is it safe to utilize in vitro reconstituted human oral epithelium? An oncogenetic pathway study
(SPRINGERDORDRECHT, 2013-08-02)
Cell therapy is a therapeutic strategy used to replace or repair damaged tissue. The epithelium transplantation of cultivated keratinocytes has been applied to several modalities of reconstruction, like oral, urethra and ...
TGF-beta autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression
(Spandidos Publ Ltd, 2012-08)
Breast cancer progression and metastasis have been linked to abnormal signaling by transforming growth factor-beta (TGF-beta) cytokines. In early-stage breast cancers, TGF-beta exhibits tumor suppressor activity by repressing ...
Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-kappa B pathway
(ELSEVIER IRELAND LTD, 2011)
Background: Topical flavonoids, such as quercetin, have been shown to reduce ultraviolet (UV) irradiation-mediated skin damage. However, the mechanisms and signaling pathways involved in this protective effect are not ...
Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum
(2012)
Background: Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this ...
Up-regulated expression of MICA on activated T lymphocytes involves Lck and Fyn kinases, and signaling through MEK1/ERK, p38 MAP kinase and calcineurin
(Federation of American Societies for Experimental Biology, 2003-06-01)
Major histocompatibility complex class I-related chain (MICA) is a cell stress-regulated molecule recognized by cytotoxic cells expressing the NKG2D molecule. MICA can be induced on T cells after CD3 or CD28 engagement. ...
The Wnt signaling pathway and rheumatoid arthritis
(ELSEVIER SCIENCE BV, 2010)
The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those ...
Central cellular signaling pathways involved with the regulation of lipid metabolism in the liver: A review
(2020-01-01)
The liver is primarily responsible for energy homeostasis and the regulation of lipid, carbohydrate and protein metabolism. Lipid metabolism consists of distributing lipids to peripheral tissues or ensuring their return ...
Excessive treadmill training enhances the insulin signaling pathway and glycogen deposition in mice hearts
(2019-02-01)
Exhaustive and chronic physical exercise leads to peripheral inflammation, which is one of the molecular mechanisms responsible for the impairment of the insulin signaling pathway in the heart. Recently, 3 different running ...
Characterization of the insulin-signaling pathway in lacrimal and salivary glands of rats
(Swets Zeitlinger PublishersLisseHolanda, 2000)
The Notch Signaling Pathway: Its Role in Focal CNS Demyelination and Apotransferrin-Induced Remyelination
(Wiley, 2013-12)
Oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Identifying the signaling pathways involved in myelin repair through oligodendroglial ...