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Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway
(2022-01-01)
Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions ...
Understanding signaling cascades in melanoma
(Wiley, 2008)
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling ...
Genital Sensory Stimulation Shifts Estradiol Intraoviductal Signaling from Nongenomic to Genomic Pathways, Independently from Prolactin Surges
(Sociedad de Biología de Chile, 2007)
Regulation of the reserve carbohydrate metabolism by alkaline pH and calcium in Neurospora crassa reveals a possible cross-regulation of both signaling pathways
(2017-06-09)
Background: Glycogen and trehalose are storage carbohydrates and their levels in microorganisms vary according to environmental conditions. In Neurospora crassa, alkaline pH stress highly influences glycogen levels, and ...
Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage
(2013-03-01)
Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) ...
Insulin-related signaling pathways elicited by light in photoreceptor nuclei from bovine retina
(Elsevier, 2015-11)
Retina light stimulation triggers phototransduction events as well as different signaling mechanisms in outer segments (sensorial portion) of photoreceptor cells. We have recently reported a novel lightdependent activation ...
Alteration in cellular viability, pro-inflammatory cytokines and nitric oxide production in nephrotoxicity generation by Amphotericin B: Involvement of PKA pathway signaling
(2013-10-11)
Amphotericin B is one of the most effective antifungal agents; however, its use is often limited owing to adverse effects, especially nephrotoxicity. The purpose of this study was to evaluate the effect of inhibiting the ...
Role of protein kinase A signaling pathway in cyclosporine nephrotoxicity
(Informa Healthcare, 2014-09-01)
Cyclosporine is an important immunosuppressive agent; however, nephrotoxicity is one of the main adverse effects. The purpose of this study was to evaluate the effect of inhibiting the protein kinase A (PKA) signaling ...
Molecular components of the Neurospora crassa pH signaling pathway and their regulation by pH and the PAC-3 transcription factor
(2016-08-01)
Environmental pH induces a stress response triggering a signaling pathway whose components have been identified and characterized in several fungi. Neurospora crassa shares all six components of the Aspergillus nidulans ...
Review: Leptin gene expression in the placenta - Regulation of a key hormone in trophoblast proliferation and survival
(Elsevier, 2011-03)
Leptin is a 16000 MW protein originally described as an adipocyte-derived signaling molecule for the central control of metabolism. However, pleiotropic effects of leptin have been identified in reproduction and pregnancy. ...