| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Chiku, Vanessa Marim | |
| dc.date | 2016-09-27T13:39:59Z | |
| dc.date | 2016-10-25T21:52:12Z | |
| dc.date | 2016-09-27T13:39:59Z | |
| dc.date | 2016-10-25T21:52:12Z | |
| dc.date | 2015-12-04 | |
| dc.date.accessioned | 2017-04-06T11:14:09Z | |
| dc.date.available | 2017-04-06T11:14:09Z | |
| dc.identifier | CHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. 67 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015. | |
| dc.identifier | http://hdl.handle.net/11449/144050 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/144050 | |
| dc.identifier | http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/14-09-2016/000870645_20170104.pdf | |
| dc.identifier | 000870645 | |
| dc.identifier | 33004021075P8 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/954309 | |
| dc.description | Dogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVC | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.language | por | |
| dc.publisher | Universidade Estadual Paulista (UNESP) | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Cães | |
| dc.subject | Leishmaniose visceral | |
| dc.subject | Leishmaniose | |
| dc.subject | Anticorpos monoclonais | |
| dc.subject | Celulas T | |
| dc.subject | Leishmania infantum | |
| dc.title | Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina | |
| dc.type | Otro | |
