The research objective was to predict the impact of techno-creators and techno-inhibitors on the different manifestations of technostress in kindergarten directors in the context of the COVID-19 pandemic and telework. The participants were INTEGRA Foundation kindergarten directors, from a sample of 567 kindergartens in Chile. To measure the technostress manifestations, the RED-TIC questionnaire was used as an instrument, and concerning techno-creators and techno-inhibitors, those established in previous research were considered. The partial least squares structural equation modeling (PLS-SEM) methodology was used, and the model estimation was performed using SmartPLS version 3.0 software. It was obtained that techno-creators correlate positively and significantly with the technostress manifestations. A negative correlation was found between techno-inhibitors and technostress manifestations and techno-creators, but not significant for skepticism and inefficacy manifestations. Therefore, it is concluded that techno-creators lead to technostress manifestations, however, techno-inhibitors did not show a significant effect in reducing these manifestations in the sample studied. Copyright © 2022 Estrada-Muñoz, Vega-Muñoz, Boada-Grau, Castillo, Müller-Pérez and Contreras-Barraza.Universitat Rovira i Virgili