Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBalcárková, Jana
dc.creatorCarvalho, Flavia Chiva
dc.creatorFerrari, Priscileila Colerato
dc.creatorCury, Beatriz Stringhetti Ferreira
dc.creatorEvangelista, Raul Cesar
dc.creatorGremião, Maria Palmira Daflon
dc.creatorCastro, Ana Dóris de
dc.date2016-01-28T16:57:11Z
dc.date2016-10-25T21:29:14Z
dc.date2016-01-28T16:57:11Z
dc.date2016-10-25T21:29:14Z
dc.date2012
dc.date.accessioned2017-04-06T09:51:39Z
dc.date.available2017-04-06T09:51:39Z
dc.identifierJournal of Pharmacy Research, v. 5, n. 6, p. 3339-3342, 2012.
dc.identifier0974-6943
dc.identifierhttp://hdl.handle.net/11449/133930
dc.identifierhttp://acervodigital.unesp.br/handle/11449/133930
dc.identifier3119063906096827
dc.identifier1327549312525180
dc.identifier0132250491238484
dc.identifier5361569184579557
dc.identifier9129780536724256
dc.identifier5579756877261098
dc.identifierhttp://connection.ebscohost.com/c/articles/84424616/chitosan-carbomer-based-tablets-containing-metronidazole-potential-treatment-periodontal-diseases
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/944459
dc.descriptionMucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases.
dc.languageeng
dc.relationJournal of Pharmacy Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMucoadhesive tablets
dc.subjectPeriodontal disease
dc.subjectMetronidazole
dc.subjectChitosan
dc.subjectCarbomer
dc.subjectDrug delivery
dc.titleChitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases
dc.typeOtro


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