Otro
Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases
Registro en:
Journal of Pharmacy Research, v. 5, n. 6, p. 3339-3342, 2012.
0974-6943
3119063906096827
1327549312525180
0132250491238484
5361569184579557
9129780536724256
5579756877261098
Autor
Balcárková, Jana
Carvalho, Flavia Chiva
Ferrari, Priscileila Colerato
Cury, Beatriz Stringhetti Ferreira
Evangelista, Raul Cesar
Gremião, Maria Palmira Daflon
Castro, Ana Dóris de
Resumen
Mucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases.