Otro
Anti-inflammatory drug design by molecular hybridization approach
Registro en:
Pharmaceuticals, v. 4, p. 1450-1474, 2011.
1424-8247
10.3390/ph4111450
ISSN1424-8247-2011-04-1450-1474.pdf
5737933639516944
3204277043366119
5435899068903487
4083068210623663
Autor
Bosquesi, Priscila Longhin
Melo, Tais Regina Ferreira
Vizioli, Ednir de Oliveira
Santos, Jean Leandro dos
Chung, Man Chin
Resumen
The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Pesquisa (CNPq)