Effect of byrosima crassa and phenolic constituents on helicobacter pylori: induced neutrophils oxdative burst

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBonacorsi, Cibele
dc.creatorRaddi, Maria Stella Gonçalves
dc.creatorFonseca, Luiz Marcos da
dc.creatorSannomiya, Mirian
dc.creatorVilegas, Wagner
dc.date2016-01-28T16:56:15Z
dc.date2016-10-25T21:28:41Z
dc.date2016-01-28T16:56:15Z
dc.date2016-10-25T21:28:41Z
dc.date2012
dc.date.accessioned2017-04-06T09:49:49Z
dc.date.available2017-04-06T09:49:49Z
dc.identifierInternational Journal of Molecular Sciences, v. 13, n. 1, p. 133-141, 2012.
dc.identifier1422-0067
dc.identifierhttp://hdl.handle.net/11449/133703
dc.identifierhttp://acervodigital.unesp.br/handle/11449/133703
dc.identifier10.3390/ijms13010133
dc.identifierISSN1422-0067-2012-13-01-133-141.pdf
dc.identifier4064204116589015
dc.identifier4795593400314888
dc.identifier4419635633356792
dc.identifier7927877224326837
dc.identifierhttp://dx.doi.org/10.3390/ijms13010133
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/944233
dc.descriptionByrsonima crassa Niedenzu (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+)-catechin > methanol extract > quercetin 3-O-α-l-arabinopyranoside > quercetin 3-O-β-d-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC50 value of 3.4 μg/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.relationInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectByrsonima crassa
dc.subjectHelicobacter pylori
dc.subjectGastric ulcers
dc.subjectAntioxidant activity
dc.subjectPhenolic compounds
dc.subjectChemiluminescence
dc.titleEffect of byrosima crassa and phenolic constituents on helicobacter pylori: induced neutrophils oxdative burst
dc.typeOtro


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