Otro
Role of α1-, and α2- and β-adrenoceptors of the median preoptic area on the water intake, renal excretion, and arterial pressure induced by ANG II
Registro en:
Brain Research, v. 717, n. 1-2, p. 38-43, 1996.
0006-8993
10.1016/0006-8993(95)01553-1
2-s2.0-0030002374
Autor
Silva, Renata Kelli Pereira da
Menani, José Vanderlei
Saad, Wilson Abrão
Renzi, Antonio
Silveira, José Eduardo Nogueira
Luiz, Aparecida Cleidionice
Camargo, Luiz Antonio de Arruda
Resumen
The present experiments were conducted to investigate the role of the α1-, α2- and β-adrenergic receptors of the median preoptic area (MnPO) on the water intake and urinary electrolyte excretion, elicited by central injections of angiotensin II (ANG II). Prazosin (an α1-adrenergic receptor antagonist) and yohimbine (an α2-adrenergic receptor antagonist) antagonized the water ingestion, Na +, K +, and urine excretion induced by ANG II. Administration of propranolol, a β-adrenergic receptor antagonist increased the Na +, K +, and urine excretion induced by ANG II. Previous treatment with prazosin and yohimbine reduced the pressor responses to ANG II. These results suggest that the adrenergic neurotransmission in the MnPO may actively participate in ANG II-induced dipsogenesis, natriuresis, kaliuresis, diuresis and pressor responses in a process that involves α1-, α2-, and β-adrenoceptors.