| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Barbosa, Marilia I. F. | |
| dc.creator | Correa, Rodrigo S. | |
| dc.creator | Pozzi, Lucas V. | |
| dc.creator | Lopes, Erica de O. | |
| dc.creator | Pavan, Fernando R. | |
| dc.creator | Leite, Clarice Q. F. | |
| dc.creator | Ellena, Javier | |
| dc.creator | Machado, Sergio de P. | |
| dc.creator | Von Poelhsitz, Gustavo | |
| dc.creator | Batista, Alzir A. | |
| dc.date | 2015-10-21T20:56:26Z | |
| dc.date | 2016-10-25T21:09:00Z | |
| dc.date | 2015-10-21T20:56:26Z | |
| dc.date | 2016-10-25T21:09:00Z | |
| dc.date | 2015-01-08 | |
| dc.date.accessioned | 2017-04-06T09:09:16Z | |
| dc.date.available | 2017-04-06T09:09:16Z | |
| dc.identifier | Polyhedron. Oxford: Pergamon-elsevier Science Ltd, v. 85, p. 376-382, 2015. | |
| dc.identifier | 0277-5387 | |
| dc.identifier | http://hdl.handle.net/11449/129367 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/129367 | |
| dc.identifier | http://dx.doi.org/10.1016/j.poly.2014.08.057 | |
| dc.identifier | WOS:000347582900047 | |
| dc.identifier | http://www.sciencedirect.com/science/article/pii/S0277538714005889 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/939922 | |
| dc.description | Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved. | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.language | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation | Polyhedron | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Mycobacterium tuberculosis | |
| dc.subject | Cytotoxicity | |
| dc.subject | Ruthenium(II) complexes | |
| dc.subject | Metallodrugs | |
| dc.subject | Hydroxypyridinecarboxylates | |
| dc.title | Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis | |
| dc.type | Otro | |
