Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCalistro Neto, José Pedro
dc.creatorTorres, Rômulo da Costa
dc.creatorGonçalves, Giovanna Maria
dc.creatorSilva, Leopoldo Muniz da
dc.creatorDomingues, Maria Aparecida Custódio
dc.creatorMódolo, Norma Sueli Pinheiro
dc.creatorBarros, Guilherme Antonio Moreira de
dc.date2015-08-26T19:22:37Z
dc.date2016-10-25T20:57:34Z
dc.date2015-08-26T19:22:37Z
dc.date2016-10-25T20:57:34Z
dc.date2015-04-01
dc.date.accessioned2017-04-06T08:50:43Z
dc.date.available2017-04-06T08:50:43Z
dc.identifierActa Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.
dc.identifier0102-8650
dc.identifierhttp://hdl.handle.net/11449/127513
dc.identifierhttp://acervodigital.unesp.br/handle/11449/127513
dc.identifierhttp://dx.doi.org/10.1590/S0102-865020150040000006
dc.identifierS0102-86502015000400270
dc.identifierS0102-86502015000400270.pdf
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270&lng=en&nrm=iso&tlng=en
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/938077
dc.descriptionTo evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.
dc.languageeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relationActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectParecoxib
dc.subjectIschemia
dc.subjectReperfusion
dc.subjectKidney
dc.subjectRats
dc.titleParecoxib reduces renal injury in an ischemia/reperfusion model in rats
dc.typeOtro


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