Interaction of cyclic and linear labaditin peptides with anionic and zwitterionic micelles

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBarbosa, S.C.
dc.creatorCilli, Eduardo Maffud
dc.creatorDias, Luis Gustavo
dc.creatorFuzo, Carlos Alessandro
dc.creatorDegrève, Léo
dc.creatorStabeli, Rodrigo G.
dc.creatorItri, Rosângela
dc.creatorCiancaglini, P.
dc.date2015-05-15T13:30:14Z
dc.date2016-10-25T20:48:28Z
dc.date2015-05-15T13:30:14Z
dc.date2016-10-25T20:48:28Z
dc.date2014
dc.date.accessioned2017-04-06T08:16:16Z
dc.date.available2017-04-06T08:16:16Z
dc.identifierJournal of Colloid and Interface Science, v. 438, p. 39-46, 2014.
dc.identifier0021-9797
dc.identifierhttp://hdl.handle.net/11449/123453
dc.identifierhttp://acervodigital.unesp.br/handle/11449/123453
dc.identifierhttp://dx.doi.org/10.1016/j.jcis.2014.09.059
dc.identifier0000-0002-4767-0904
dc.identifier9424346762460416
dc.identifier2226887922453028
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0021979714007085
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/934066
dc.descriptionConformational changes of the cyclic (Lo) peptide Labaditin (VWTVWGTIAG) and its linear analogue (L1) promoted by presence of anionic sodium dodecyl sulfate (SDS) and zwitterionic L-α-Lysophosphatidylcholine (LPC) micelles were investigated. Results from λmax blue-shift of tryptophan fluorescence emission combined with Stern–Volmer constants values and molecular dynamics (MD) simulations indicated that L1 interacts with SDS micelles to a higher extent than does Lo. Further, the MD simulation demonstrated that both Lo and L1 interact similarly with LPC micelles, being preferentially located at the micelle/water interface. The peptide–micelle interaction elicits conformational changes in the peptides. Lo undergoes limited modifications and presents unordered structure in both LPC and SDS micelles. On the other hand, L1 displays a random-coil structure in aqueous medium, pH 7.0, and it acquires a β-structure upon interaction with SDS and LPC, albeit with structural differences in each medium.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.relationJournal of Colloid and Interface Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLabaditin
dc.subjectCyclic peptide
dc.subjectCircular dichroism
dc.subjectFluorescence
dc.subjectMolecular dynamic
dc.titleInteraction of cyclic and linear labaditin peptides with anionic and zwitterionic micelles
dc.typeOtro


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