Otro
Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca
Registro en:
Molecules. Basel: Mdpi Ag, v. 19, n. 11, p. 19243-19252, 2014.
1420-3049
10.3390/molecules191119243
WOS:000345564300128
WOS000345564300128.pdf
0000-0001-7616-9652
Autor
Chapla, Vanessa Mara
Zeraik, Maria Luiza
Leptokarydis, Ioanis Hcristos
Silva, Geraldo Humberto
Bolzani, Vanderlan da Silva
Young, Maria Claudia M.
Pfenning, Ludwig Heinrich
Araújo, Angela Regina
Resumen
In this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl) acetic acid (6), 4-hydroxy-benzamide (7) and 2(2-hydroxyphenyl) acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1-8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)