| dc.creator | Tangella, Yellaiah | |
| dc.creator | Prakash Soni, Jay | |
| dc.creator | Shankaraiah, Nagula | |
| dc.creator | abril, diana | |
| dc.creator | Sathish, Manda | |
| dc.date | 2023-05-02T19:08:31Z | |
| dc.date | 2023-05-02T19:08:31Z | |
| dc.date | 2023 | |
| dc.date.accessioned | 2024-05-02T20:31:09Z | |
| dc.date.available | 2024-05-02T20:31:09Z | |
| dc.identifier | http://repositorio.ucm.cl/handle/ucm/4740 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9274978 | |
| dc.description | A versatile and efficient one-pot protocol has been developed for the synthesis of amides from easily
accessible carboxylic acids and amines by employing trimethylsilyl azide as a promoter at room temperature.
This reaction proceeds via an in situ generated acyl azide intermediates followed by the nucleophilic
substitution of amines. Notably, most of the desired amides were obtained by simple filtration in excellent
yields. The significant advantages like metal-free mild reaction conditions, higher yields, easily removable
volatile byproducts, operational simplicity, and broad substrate scope make the transformation a useful
contribution for the synthesis of biologically important amides. | |
| dc.language | en | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.source | Arkivoc, 2023(6), 202211914 | |
| dc.subject | Amide coupling | |
| dc.subject | Amine | |
| dc.subject | Peptide | |
| dc.subject | Carboxylic acid | |
| dc.subject | Trimethylsilyl azide | |
| dc.title | Trimethylsilyl azide-promoted acid-amine coupling: a facile one-pot route to amides from carboxylic acids and amines | |
| dc.type | Article | |
