Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants

dc.creatorPetermann-Rocha, Fanny
dc.creatorWirth, Michael D.
dc.creatorBoonpor, Jirapitcha
dc.creatorParra‑Soto, Solange
dc.creatorZhou, Ziyi
dc.creatorMathers, John
dc.creatorLivingstone, Katherine M.
dc.creatorForrest, Ewan
dc.creatorPell, J.P.
dc.creatorHo, Frederick
dc.creatorHébert, James R
dc.creatorCelis-Morales, Carlos
dc.date2023-04-25T14:12:06Z
dc.date2023-04-25T14:12:06Z
dc.date2023
dc.date.accessioned2024-05-02T20:31:05Z
dc.date.available2024-05-02T20:31:05Z
dc.identifierhttp://repositorio.ucm.cl/handle/ucm/4706
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9274946
dc.descriptionBackground Although non-alcoholic fatty liver disease (NAFLD) is linked to infammation, whether an infammatory diet increases the risk of NAFLD is unclear. This study aimed to examine the association between the Energy-adjusted Diet Infammatory Index (E-DII) score and severe NAFLD using UK Biobank. Methods This prospective cohort study included 171,544 UK Biobank participants. The E-DII score was computed using 18 food parameters. Associations between the E-DII and incident severe NAFLD (defned as hospital admission or death) were frst investigated by E-DII categories (very/moderately anti-infammatory [E-DII< −1], neutral [E-DII−1 to 1] and very/moderately pro-infammatory [E-DII>1]) using Cox proportional hazard models. Nonlinear associa‑ tions were investigated using penalised cubic splines ftted into the Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. Results Over a median follow-up of 10.2 years, 1489 participants developed severe NAFLD. After adjusting for confounders, individuals in the very/moderately pro-infammatory category had a higher risk (HR: 1.19 [95% CI: 1.03 to 1.38]) of incident severe NAFLD compared with those in the very/moderately anti-infammatory category. There was some evidence of nonlinearity between the E-DII score and severe NAFLD. Conclusions Pro-infammatory diets were associated with a higher risk of severe NAFLD independent of confound‑ ers such as the components of the metabolic syndrome. Considering there is no recommended treatment for the disease, our fndings suggest a potential means to lower the risk of NAFLD.
dc.languageen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceBMC Medicine, 21(1), 123
dc.subjectDiet
dc.subjectNon-alcoholic fatty liver disease
dc.subjectIncidence
dc.subjectInfammation
dc.subjectProspective studies
dc.titleAssociations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants
dc.typeArticle


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