artículo
LITHIUM: MOLECULAR INTERACTIONS, CLINICAL ACTIONS
Fecha
2012Registro en:
10.2478/s13380-012-0011-3
2081-6936
2081-3856
WOS:000304698400011
Autor
Catalan, Johanna F.
Paz Quezada, Maria
Institución
Resumen
Lithium is one of the most widely used drugs in neuropsychopharmacology. Preclinical scientists have made several advances in ascertaining the molecular mechanisms of action of this cation; such as its ability to stabilize monoamine levels, to interact with second messengers, and its neuroprotective effects, possibly over suicidal behaviors. Nevertheless, there remains a gap of knowledge between the pharmacological advances and the number of reliable clinical trials, creating a lack of evidence-based medicine to support medical prescriptions. In this review we examine lithium's molecular mechanisms of action and evaluate their relevance in clinical applications.