Balanced anesthesia with sevoflurane does not alter redox status in patients undergoing surgical procedures

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorOrosz, Jose Eduardo B.
dc.creatorBraz, Leandro Gobbo
dc.creatorFerreira, Ana Lúcia dos Anjos
dc.creatorAmorim, Rosa Beatriz
dc.creatorSalvadori, Daisy Maria Favero
dc.creatorYeum, Kyung-Jin
dc.creatorBraz, José Reinaldo Cerqueira
dc.creatorBraz, Mariana Gobbo
dc.date2015-03-18T15:53:42Z
dc.date2016-10-25T20:25:21Z
dc.date2015-03-18T15:53:42Z
dc.date2016-10-25T20:25:21Z
dc.date2014-10-01
dc.date.accessioned2017-04-06T07:05:08Z
dc.date.available2017-04-06T07:05:08Z
dc.identifierMutation Research-genetic Toxicology And Environmental Mutagenesis. Amsterdam: Elsevier Science Bv, v. 773, p. 29-33, 2014.
dc.identifier1383-5718
dc.identifierhttp://hdl.handle.net/11449/116673
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116673
dc.identifier10.1016/j.mrgentox.2014.07.007
dc.identifierWOS:000343948900005
dc.identifier0000-0003-4413-226X
dc.identifierhttp://dx.doi.org/10.1016/j.mrgentox.2014.07.007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927320
dc.descriptionDespite the effectiveness and safety of anesthetics, some unanswered questions remain concerning their toxicity and effects on cellular redox balance. To test for possible toxic effects of balanced anesthesia maintained with the volatile anesthetic sevoflurane, we evaluated oxidative stress during and after general anesthesia in 15 adult patients without comorbidities who underwent elective minor surgical procedures. Venous blood samples were collected at baseline, before anesthesia (t0); after anesthesia induction and immediately before surgery (t1); 2 h after the beginning of anesthesia (t2); and on the day following surgery (t3). Antioxidant defense was determined by fluorometry. Oxidative stress markers included oxidative DNA damage, evaluated by the alkaline comet assay, and plasma malondialdehyde (MDA), assessed by high performance liquid chromatography (HPLC). No increase in oxidized DNA damage or antioxidant defense was observed. Plasma MDA increased only at t3 compared with t2. Balanced sevoflurane-maintained anesthesia appears neither to damage DNA nor to alter redox status. (C) 2014 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMutation Research-genetic Toxicology And Environmental Mutagenesis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInhalation anesthetics
dc.subjectGenotoxicity test
dc.subjectOxidative stress
dc.subjectMinor surgery
dc.titleBalanced anesthesia with sevoflurane does not alter redox status in patients undergoing surgical procedures
dc.typeOtro


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