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Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure
Fecha
2005Registro en:
10.1016/j.amjcard.2005.03.057
1879-1913
0002-9149
MEDLINE:16018855
WOS:000230532500021
Autor
Castro, PF
Mc Nab, P
Quintana, JC
Bittner, A
Greig, D
Vergara, I
Vukasovic, JL
Corbalan, R
Copaja, M
Diaz Araya, G
Chiong, M
Troncoso, R
Alcaino, H
Lavandero, S
Institución
Resumen
Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes. (c) 2005 Elsevier Inc. All rights reserved.