Otro
Blood Profile and Histology in Oral Infections Associated with Diabetes
Registro en:
Journal Of Endodontics. New York: Elsevier Science Inc, v. 40, n. 8, p. 1139-1144, 2014.
0099-2399
10.1016/j.joen.2014.01.034
WOS:000340686400016
Autor
Cintra, Luciano Tavares Angelo
Silva Facundo, Aguinaldo Candido da
Carrara Prieto, Annelise Katrine
Sumida, Doris Hissako
Narciso, Luis Gustavo
Bomfim, Suely Regina Mogami
Oliveira e Silva, Cleverson
Dezan Júnior, Eloi
Gomes-Filho, Joao Eduardo
Resumen
Introduction: We aimed to investigate the relationship between blood profile and histologic findings in both apical periodontitis (AP) and periodontal disease (PD) associated with diabetes. Methods: Wistar rats (N = 80) were assigned to the following 8 groups: control, AP, PD, AP associated with PD, diabetes, diabetes with AP, diabetes with PD, and diabetes with AP and PD. Diabetes mellitus (DM) was induced with streptozotocin, AP was induced by exposure to the oral environment, and PD was induced using periodontal ligature. After 30 days, blood samples were collected, and the rats were euthanized. Subsequently, the maxillae were processed for light microscopy. Hematologic examinations were conducted to determine the total number of erythrocytes and leukocytes, erythrocyte constant, and blood glucose level. One-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at P < .05. Results: A significant correlation was found between the histologic findings and blood parameters. Conclusions: In conclusion, diabetes accelerated the development and progression of AP and PD in the rats and caused an increase in the average erythrocyte volume as well as the leukocyte and neutrophil counts. Oral infections increase the total number of leukocytes, the number of neutrophils and lymphocytes, and blood glucose concentrations in DM rats. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)