artículo
Associations of the CTLA-4 polymorphism with type 1 diabetes in Chilean population: case-parent design
Fecha
2009Registro en:
10.1016/j.diabres.2009.05.019
0168-8227
Autor
Angel, Bárbara
Balic, Iván
Santos Martín, José Luis
Codner, Ethel
Carrasco, Elena
Pérez-Bravo, Francisco
Institución
Resumen
CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p = 0.028) was observed, possibly due to an overtransmission of the G-T haplotype. (C) 2009 Elsevier Ireland Ltd. All rights reserved.