artículo
An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome
Fecha
2011Registro en:
10.3109/14767058.2010.507294
1476-4954
1476-7058
MEDLINE:20701435
WOS:000286993000001
Autor
Vaisbuch, Edi
Romero, Roberto
Gomez, Ricardo
Kusanovic, Juan Pedro
Mazaki Tovi, Shali
Chaiworapongsa, Tinnakorn
Hassan, Sonia S.
Institución
Resumen
Methods. aEuro integral Fetal blood sampling was performed in sensitized Rh-D negative women with suspected fetal anemia (n aEuroS== aEuroS16). Fetal anemia was diagnosed according to reference range nomograms established for the assessment of fetal hematologic parameters. An elevated fetal plasma IL-6 concentration was defined using a cutoff of > 11 pg/ml. Concentrations of IL-6 were determined by immunoassay. Non-parametric statistics were used for analysis. Results. aEuro integral(1) The prevalence of an elevated fetal plasma IL-6 was 25%% (4/16); (2) there was an inverse relationship between the fetal hematocrit and IL-6 concentration -- the lower the hematocrit, the higher the fetal IL-6 (r aEuroS== aEuroS--0.68, p aEuroS== aEuroS0.004); (3) fetuses with anemia had a significantly higher plasma IL-6 concentration than those without anemia (3.74 pg/ml, interquartile range (IQR) 1.18--2.63 vs. 1.46 pg/ml, IQR 1.76--14.7; p aEuroS== aEuroS0.02); (4) interestingly, all fetuses with an elevated plasma IL-6 concentration had anemia (prevalence 40%%, 4/10), while in the group without anemia, none had an elevated fetal plasma IL-6. Conclusions. aEuro integral An elevation in fetal plasma IL-6 can be observed in a subset of fetuses with anemia due to Rh alloimmunization. This observation suggests that the hallmark of FIRS can be caused by non-infection-related insults. Further studies are required to determine whether the prognosis of FIRS caused by intra-amniotic infection/inflammation is different from that induced by alloimmunization.