artículo
Gelastic epilepsy: Beyond hypothalamic hamartomas
Fecha
2015Registro en:
10.1016/j.ebcr.2015.07.001
2589-9864
Autor
Uribe-San-Martin, Reinaldo
Ciampia, Ethel
Lawson-Peralta, Balduin
Acevedo-Gallinato, Keryma
Torrealba-Marchant, Gonzalo
Campos-Puebla, Manuel
Godoy-Fernández, Jaime
Institución
Resumen
Gelasticepilepsyorlaughingseizureshavebeenhistoricallyrelatedtochildrenwithhypothalamichamartomas. Wereportthreeadultpatientswhohadgelasticepilepsy,definedasthepresenceofseizureswithaprominent laughcomponent,includingbrainimaging,surface/invasiveelectroencephalography,positronemissiontomography,andmedical/surgicaloutcomes.Noneofthepatientshadhamartomaorotherhypothalamiclesion.Two patientswereclassifiedashavingrefractoryepilepsy(onehadbiopsy-provenneurocysticercosisandtheother onehippocampalsclerosisandtemporalcorticaldysplasia).ThethirdpatienthadnolesiononMRIandhad completecontrolwithcarbamazepine.Bothlesionalpatientsunderwentresectivesurgery,onewithcomplete seizurecontrolandtheotheronewithpooroutcome.Althoughhypothalamichamartomasshouldalways beruledoutinpatientswithgelasticepilepsy, laughingseizurescanalsoarisefromfrontalandtemporal lobefoci,whichcanbesurgicallyremoved. Inaddition,wepresentthefirstcaseofgelasticepilepsydueto neurocysticercosis.