artículo de revisión
Sedation and Analgesia for Toxic Epidermal Necrolysis in the Intensive Care Unit: Few Certainties, Many Questions Ahead
Fecha
2023Registro en:
10.3390/jpm13081194
2075-4426
37623445
SCOPUS_ID: 85169065991
WOS:001057105400001
Autor
Kattan Tala, Eduardo José
Elgueta Le-beuffe, Maria Francisca
Merino, Sebastian
Retamal Montes, Jaime Alejandro
Institución
Resumen
Toxic epidermal necrolysis (TEN) is a rare, acute mucocutaneous life-threatening disease. Although research has focused on the pathophysiological and therapeutic aspects of the disease, there is a paucity of data in the literature regarding pain management and sedation in the intensive care unit (ICU). Most therapies have been extrapolated from other situations and/or the general ICU population. These patients present unique challenges during the progression of the disease and could end up requiring invasive mechanical ventilation due to inadequate pain management, which is potentially avoidable through a comprehensive treatment approach. In this review, we will present clinical and pathophysiological aspects of TEN, analyze pain pathways and relevant pharmacology, and propose therapeutic alternatives based on a rational and multimodal approach.