Is there a role for herpes simplex virus type 1 in multiple sclerosis?

Abstract

Numerous studies relate the onset and severity of multiple sclerosis (MS) with viral infections. Herpes simplex virus type 1 (HSV-1), which is neurotropic and highly prevalent in the brain of healthy in-dividuals, has been proposed to relate to MS. Here, we review and discuss the reported connections between HSV-1 and MS.(c) 2022 The Author(s). Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).