Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children

dc.creatorToro, C.S.
dc.creatorFarfán, M.
dc.creatorContreras, I.
dc.creatorFlores, O.
dc.creatorNavarro, N.
dc.creatorMora, G.C.
dc.creatorPrado, V.
dc.date.accessioned2023-10-16T11:50:55Z
dc.date.accessioned2024-05-02T15:08:35Z
dc.date.available2023-10-16T11:50:55Z
dc.date.available2024-05-02T15:08:35Z
dc.date.created2023-10-16T11:50:55Z
dc.date.issued2005-02
dc.identifierEpidemiology and Infection, Volume 133, Issue 1, Pages 81 - 86, February 2005
dc.identifier09502688
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/53470
dc.identifier10.1017/S0950268804003048
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9263145
dc.description.abstractA total of 162 clinical isolates of Shigella collected from children in a semi-rural community of Chile were examined for the presence of genetic determinants of resistance to ampicillin, chloramphenicol, tetracycline, and trimethoprim. Ampicillin resistance was most frequently associated with the presence of blaOXA in S. flexneri and with blaTEM in S. sonnei. The blaOXA gene but not blaTEM was located in class 1 integrons. The dhfrla gene encoding for resistance to trimethoprim was associated to class 2 integrons and detected exclusively in S. flexneri, whereas dhfrIIIc was found in all S. sonnei strains and in 10% of the S. flexneri isolates. Cat, coding for choramphenicol resistance, and blaOXA genes were located in the chromosome in all cases, whereas tetA gene, coding for tetracycline resistance, and blaTEM, dhfrIa and dhfrIIIc genes were found either in the chromosome or in conjugative plasmids. Our results show a heterogenous distribution of antibiotic-resistance determinants between S. flexneri and S. sonnei. © 2004 Cambridge University Press.
dc.languageen
dc.publisherCambridge University Press
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/deed.en
dc.rightsCC BY-NC-SA 4.0 DEED Attribution-NonCommercial-ShareAlike 4.0 International
dc.subjectBlotting, Southern
dc.subjectChild
dc.subjectChile
dc.subjectDrug Resistance, Multiple, Bacterial
dc.subjectDysentery, Bacillary
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPlasmids
dc.subjectPolymerase Chain Reaction
dc.subjectRural Population
dc.subjectShigella flexneri
dc.subjectShigella sonnei
dc.titleGenetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children
dc.typeArtículo


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