Artículo
Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
Fecha
2014Registro en:
1420-3049
10.3390/molecules191118993
Autor
Montenegro, Ivan
Tomasoni, Giacomo
Bosio, Claudia
Quiñones, Natalia
Madrid, Alejandro
Carrasco, Hector
Olea, Andres
Martinez, Rolando
Cuellar, Mauricio
Villena, Joan
Institución
Resumen
Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.