PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications

dc.creatorTorres, Cecilia C.
dc.creatorCampos, Cristian H.
dc.creatorDiáz, Carola
dc.creatorJiménez, Verónica A.
dc.creatorVidal, Felipe
dc.creatorGuzmán, Leonardo
dc.creatorAlderete, Joel B.
dc.date.accessioned2023-09-22T13:30:19Z
dc.date.accessioned2024-05-02T14:49:57Z
dc.date.available2023-09-22T13:30:19Z
dc.date.available2024-05-02T14:49:57Z
dc.date.created2023-09-22T13:30:19Z
dc.date.issued2016-08
dc.identifierMaterials Science and Engineering C Volume 65, Pages 164 - 1711 August 2016
dc.identifier0928-4931
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/53284
dc.identifier10.1016/j.msec.2016.03.104
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9259025
dc.description.abstractPAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes. © 2016 Elsevier B.V. All rights reserved.
dc.languageen
dc.publisherElsevier Ltd
dc.rightshttps://creativecommons.org/licenses/by/4.0/deed.es
dc.rightsAtribución 4.0 Internacional (CC BY 4.0)
dc.subjectDrug delivery
dc.subjectPAMAM dendrimers
dc.subjectSmall molecule drugs
dc.subjectTiO2 nanotubes
dc.titlePAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications
dc.typeArtículo


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