Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDejani, Naiara N.
dc.creatorSouza, Lais C.
dc.creatorOliveira, Sandra R. P.
dc.creatorNeris, Debora M.
dc.creatorRodolpho, Joice M. A.
dc.creatorCorreia, Ricardo O.
dc.creatorRodrigues, Vanderlei
dc.creatorSacramento, Luis V. S.
dc.creatorFaccioli, Lucia H.
dc.creatorAfonso, Ana
dc.creatorAnibal, Fernanda F.
dc.date2014-12-03T13:11:44Z
dc.date2016-10-25T20:14:59Z
dc.date2014-12-03T13:11:44Z
dc.date2016-10-25T20:14:59Z
dc.date2014-08-01
dc.date.accessioned2017-04-06T06:33:58Z
dc.date.available2017-04-06T06:33:58Z
dc.identifierImmunobiology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 219, n. 8, p. 627-632, 2014.
dc.identifier0171-2985
dc.identifierhttp://hdl.handle.net/11449/113484
dc.identifierhttp://acervodigital.unesp.br/handle/11449/113484
dc.identifier10.1016/j.imbio.2014.03.015
dc.identifierWOS:000338004500007
dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2014.03.015
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/924226
dc.descriptionSchistosomiasis is a chronic disease caused by an intravascular trematode of the genus Schistosoma. Praziquantel is the drug used for treatment of schistosomiasis; nevertheless failure of treatment has been reported. Consequently, the identification of new effective schistosomicidal compounds is essential to ensure the effective control of schistosomiasis in the future. In this work we investigated the immunomodulatory and antiparasitic effects of the crude leaves extract of Mentha x piperita L. (peppermint) on murine Schistosomiasis mansoni. Female Balb/c mice were infected each with 50 S. mansoni cercariae and divided into three experimental groups: (I) untreated; (II) treated daily with M. x piperita L (100 mg/kg) and III) treated on 1/42/43 days post-infection with Praziquantel (500 mg/kg). Another group with uninfected and untreated mice was used as a control. Subsequently, seven weeks post-infection, S. mansoni eggs were counted in the feces, liver and intestine. Worms were recovered by perfusion of the hepatic portal system and counted. Sera levels of IL-10, IL-5, IL-13, IFN-gamma, IgG1, IgE and IgG2a were assayed by ELISA. Animals treated with a daily dose of M. x piperita L showed increased sera levels of IL-10, IFN-gamma, IgG2a and IgE. Besides, M. x piperita L. treatment promoted reduction in parasite burden by 35.2% and significant decrease in egg counts in the feces and intestine. (C) 2014 Elsevier GmbH. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationImmunobiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMentha x piperita L.
dc.subjectSchistosoma mansoni
dc.subjectImmunomodulation
dc.subjectAntiparasitic
dc.titleImmunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.
dc.typeOtro


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