Otro
Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
Registro en:
Molecules. Basel: Mdpi Ag, v. 19, n. 5, p. 6597-6608, 2014.
1420-3049
10.3390/molecules19056597
WOS:000337113000070
WOS000337113000070.pdf
0000-0001-7616-9652
Autor
Chapla, Vanessa Mara
Zeraik, Maria Luiza
Ximenes, Valdecir F.
Zanardi, Lisineia Maria
Lopes, Márcia Nasser
Cavalheiro, Alberto José
Silva, Dulce Helena Siqueira
Young, Maria Claudia M.
Fonseca, Luiz Marcos da
Bolzani, Vanderlan da Silva
Araújo, Angela Regina
Resumen
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)