Otro
Downmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNS
Registro en:
Journal Of Neuroimmunology. Amsterdam: Elsevier Science Bv, v. 268, n. 1-2, p. 35-42, 2014.
0165-5728
10.1016/j.jneuroim.2013.12.015
WOS:000333730200004
Autor
Goncalves Zorzella-Pezavento, Sofia Fernanda
Chiuso-Minicucci, Fernanda
Donega Franca, Thais Graziela
Watanabe Ishikawa, Larissa Lumi
Rosa, Larissa Camargo da
Colavite, Priscila Maria
Marques, Camila
Valerio Ikoma, Maura Rosane
Silva, Celio Lopes
Sartori, Alexandrina
Resumen
Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE. (C) 2014 Elsevier B.V. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)