Cutting Edge: NADPH Oxidase Modulates MHC Class II Antigen Presentation by B Cells

dc.creatorArias Sierra, Andrés Augusto
dc.creatorMatute Yepes, Juan David
dc.creatorCrotzer, Victoria L.
dc.creatorZhao, Heng
dc.creatorQuilliam, Lawrence A.
dc.creatorDinauer, Mary C.
dc.creatorBlum, Janice S.
dc.date2023-03-29T16:58:57Z
dc.date2023-03-29T16:58:57Z
dc.date2012
dc.date.accessioned2024-04-23T18:17:44Z
dc.date.available2024-04-23T18:17:44Z
dc.identifierCrotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS. Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol. 2012 Oct 15;189(8):3800-4. doi: 10.4049/jimmunol.1103080.
dc.identifier0022-1767
dc.identifierhttps://hdl.handle.net/10495/34336
dc.identifier10.4049/jimmunol.1103080
dc.identifier1550-6606
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9230641
dc.descriptionABSTRACT: Phagocyte NADPH oxidase plays a key role in pathogen clearance via reactive oxygen species (ROS) production. Defects in oxidase function result in chronic granulomatous disease with hallmark recurrent microbial infections and inflammation. The oxidase’s role in the adaptive immune response is not well understood. Class II presentation of cytoplasmic and exogenous Ag to CD4+ T cells was impaired in human B cells with reduced oxidase p40phox subunit expression. Naturally arising mutations, which compromise p40phox function in a chronic granulomatous disease patient, also perturbed class II Ag presentation and intracellular ROS production. Reconstitution of patient B cells with a wild-type, but not a mutant, p40phox allele restored exogenous Ag presentation and intracellular ROS generation. Remarkably, class II presentation of epitopes from membrane Ag was robust in p40phox-deficient B cells. These studies reveal a role for NADPH oxidase and p40phox in skewing epitope selection and T cell recognition of self Ag.
dc.descriptionCOL0012426
dc.descriptionCOL0038389
dc.format5
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAsociación Estadounidense de Inmunólogos
dc.publisherInmunodeficiencias Primarias
dc.publisherInmunomodulación
dc.publisherBaltimore, Estados Unidos
dc.relationJ. Immunol.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectB-Lymphocytes
dc.subjectLinfocitos B
dc.subjectNADPH Oxidases
dc.subjectNADPH Oxidasas
dc.subjectB-Cell Activating Factor
dc.subjectFactor Activador de Células B
dc.subjectGenes, MHC Class II
dc.subjectGenes MHC Clase II
dc.subjectB-Cell Maturation Antigen
dc.subjectAntígeno de Maduración de Linfocitos B
dc.titleCutting Edge: NADPH Oxidase Modulates MHC Class II Antigen Presentation by B Cells
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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