Solvent effect on photostability of butyl methoxy di benzoyl methane formulated in solution and emulsion

dc.creatorDurango Álvarez, Enith Susana
dc.creatorCastaneda Henao, Stephanie
dc.creatorVallejo Ocampo, John Jairo
dc.creatorGallardo Cabrera, Cecilia
dc.date2023-06-30T14:59:49Z
dc.date2023-06-30T14:59:49Z
dc.date2015
dc.date.accessioned2024-04-23T18:03:28Z
dc.date.available2024-04-23T18:03:28Z
dc.identifierDurango, S. & Castañeda, S. & Vallejo, J. & Gallardo, C.. (2015). Solvent effect on photostability of butyl methoxy di benzoyl methane formulated in solution and emulsion. International Journal of Pharmacy and Pharmaceutical Sciences. 7. 181-186.
dc.identifier0975-1491
dc.identifierhttps://hdl.handle.net/10495/35728
dc.identifier2656-0097
dc.identifierhttps://innovareacademics.in/journals/index.php/ijpps
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9230336
dc.descriptionABSTRACT: Objective: The current study was undertaken to correlate the impact of some cosmetics solvents in the photostability of butyl methoxy dibenzoyl methane (BMDBM) into systems with an increasing order of complexity, from simple solutions to emulsions. Methods: Solutions and emulsions containing BMDBM in different solvents were prepared and evaluated using spectrophotometer or transmittance analyzer, respectively. Also, emulsions containing BMDBM in combination with octyl methoxycinnamate (OMC) in ratio 1:1 and 1: 2, and in the presence of octocrylene in the ratio 1:2:1 were prepared. The percentage of decay absorbance at 356 nm was measured before and after irradiation at 500 W/m2 Results: The absorbance decay of BMDBM in solution was higher in solvents such as mineral oil, isopropyl palmitate and isopropyl myristate. Also, it was observed that concentration and degassing had an effect on the decay kinetics. In emulsions containing only, BMDBM, the absorbance decay did not exceed 20% in all solvents, suggesting a protective effect of the matrix. In the contrary, a decay of 90% was observed in emulsion containing BMDBM and OMC in a 1:2 ratio. When Oct was added to that emulsion, stabilization on the absorbance decay of BMDBM was detected. at intervals of 20 min until completing 100 min. Finally, a photolysis assay was carried to analyze deoxygenated and not BMDBM solutions. Conclusion: This study evidenced that the photochemistry of BMDBM is different in solutions and in emulsions. In solutions, the nature of solvents was important, while in emulsions the nature of UVB filters played a pivotal role in the stability of BMDBM.
dc.descriptionCOL0035117
dc.format6
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherIJPPS
dc.publisherGrupo de Estabilidad de Medicamentos, Cosméticos y Alimentos (GEMCA)
dc.publisherBhopal, India
dc.relationInt. J. Pharm. Pharm. Sci.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectButanoles
dc.subjectButanols
dc.subjectCombinación Adapaleno y Peróxido de Benzoílo
dc.subjectAdapalene, Benzoyl Peroxide Drug Combination
dc.subjectEmulsiones
dc.subjectEmulsions
dc.subjectIndustria Cosmética
dc.subjectCosmetic Industry
dc.subjectFotoquímica
dc.subjectPhotochemistry
dc.titleSolvent effect on photostability of butyl methoxy di benzoyl methane formulated in solution and emulsion
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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