Benzophenone guttiferone A from Garcinia achachairu Rusby (Clusiaceae) Presents Genotoxic Effects in Different Cells of Mice

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTerrazas, Peterson Menezes
dc.creatorMarques, Eduardo de Souza
dc.creatorBolda Mariano, Luisa Nathalia
dc.creatorCechinel-Filho, Valdir
dc.creatorNiero, Rivaldo
dc.creatorAndrade, Sergio Faloni
dc.creatorMaistro, Edson Luis
dc.date2014-12-03T13:10:28Z
dc.date2016-10-25T20:10:32Z
dc.date2014-12-03T13:10:28Z
dc.date2016-10-25T20:10:32Z
dc.date2013-11-08
dc.date.accessioned2017-04-06T06:19:49Z
dc.date.available2017-04-06T06:19:49Z
dc.identifierPlos One. San Francisco: Public Library Science, v. 8, n. 11, 6 p., 2013.
dc.identifier1932-6203
dc.identifierhttp://hdl.handle.net/11449/112158
dc.identifierhttp://acervodigital.unesp.br/handle/11449/112158
dc.identifier10.1371/journal.pone.0076485
dc.identifierWOS:000327216200006
dc.identifierWOS000327216200006.pdf
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0076485
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922925
dc.descriptionBenzophenones from natural sources and those of synthetic analogues present several reports of potent biological properties, and Guttiferone A represents a promising medicinal natural compound with analgesic and gastroprotective profiles. Considering that there are no reports that assess the genetic toxicity of Guttiferone A, the present study was undertaken to investigate the genotoxic potential of this benzophenone isolated from seeds of Garcinia achachairu in terms of DNA damage in different cells of Swiss albino mice using the comet assay, and its clastogenic/aneugenic effects in bone marrow cells in vivo by the micronucleus test. Cytotoxicity was assessed by scoring polychromatic (PCE) and normochromatic (NCE) erythrocytes ratio. Guttiferone A was administered by oral gavage at doses of 15, 30 and 60 mg/kg. The results showed that Guttiferone A produced genotoxic effects in leukocytes, liver, bone marrow, brain and testicle cells and clastogenic/aneugenic effects in bone marrow erythrocytes of mice. The PCE/NCE ratio indicated no cytotoxicity. Since guttiferone A is harmful to the genetic material we suggest caution in its use by humans.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherPublic Library Science
dc.relationPLOS ONE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleBenzophenone guttiferone A from Garcinia achachairu Rusby (Clusiaceae) Presents Genotoxic Effects in Different Cells of Mice
dc.typeOtro


Este ítem pertenece a la siguiente institución