info:eu-repo/semantics/article
Transcriptional reprogramming of gene expression in bovine somatic cell chromatin transfer embryos
Registro en:
Rodríguez-Osorio N, Wang Z, Kasinathan P, Page GP, Robl JM, Memili E. Transcriptional reprogramming of gene expression in bovine somatic cell chromatin transfer embryos. BMC Genomics. 2009 Apr 24;10:190. doi: 10.1186/1471-2164-10-190.
10.1186/1471-2164-10-190.
1471-2164
Autor
Rodríguez Osorio, Nélida
Wang, Zhongde
Kasinathan, Poothappillai
Page, Grier P.
Robl, James M.
Memili, Erdogan
Institución
Resumen
ABSTRACT: Background: Successful reprogramming of a somatic genome to produce a healthy clone by
somatic cells nuclear transfer (SCNT) is a rare event and the mechanisms involved in this process
are poorly defined. When serial or successive rounds of cloning are performed, blastocyst and full
term development rates decline even further with the increasing rounds of cloning. Identifying the
"cumulative errors" could reveal the epigenetic reprogramming blocks in animal cloning. COL0001262