Effect of Qualea multiflora on Macrophages and Tumour Cells

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarli, Camila B. de A.
dc.creatorQuilles, Marcela B.
dc.creatorVilegas, Wagner
dc.creatorCarlos, Iracilda Zeppone
dc.date2014-12-03T13:08:36Z
dc.date2016-10-25T20:08:24Z
dc.date2014-12-03T13:08:36Z
dc.date2016-10-25T20:08:24Z
dc.date2013-01-01
dc.date.accessioned2017-04-06T06:12:39Z
dc.date.available2017-04-06T06:12:39Z
dc.identifierLatin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 32, n. 10, p. 1516-1521, 2013.
dc.identifier0326-2383
dc.identifierhttp://hdl.handle.net/11449/111385
dc.identifierhttp://acervodigital.unesp.br/handle/11449/111385
dc.identifierWOS:000331253000012
dc.identifierhttp://www.latamjpharm.org/resumenes/32/10/LAJOP_32_10_1_12.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922165
dc.descriptionSpecies of the genus Qualea are used by the Brazilian people as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions beta F and TF (rich in beta-sitosterol and terpenoids, respectively) obtained from Qualea multiflora on nitric oxide production, cytokines (IL-1, IL-10, IL-12, and TNF-alpha) and the transcription factor NF-kappa B by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of beta F and TF against mammary and pulmonary tumoural cell lineages, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-alpha; about 32% of NF-kappa B; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to beta F and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherColegio Farmaceuticos Provincia de Buenos Aires
dc.relationLatin American Journal of Pharmacy
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer
dc.subjectMacrophages
dc.subjectQualea multiflora
dc.titleEffect of Qualea multiflora on Macrophages and Tumour Cells
dc.typeOtro


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