La pandemia de la covid-19 implica una crisis impactante para la época contemporánea en la salud pública. La cual se ha logrado atenuar por los estudios emergentes de la comunidad científica. Para generar colaboraciones, destacando el acelerador ACT y sus avances de laboratorio sobre las vacunas. Consecuentemente la escasez de valiosa información sobre farmacovigilancia vinculada con los distintos factores sociodemográficos. Por lo tanto, genera una posibilidad para crear estrategias educativas sobre los procesos de vacunación que tienen como objetivo la expansión colectiva de manera sistemática y controlada. Objetivo: Establecer las reacciones adversas y efectos secundarios suscitados en el personal de salud para generar estrategias para una vacunación más efectiva. Metodología: Se realizó un estudio observacional descriptivo, tipo serie de casos en personal de salud mayor de 18 años con esquema de vacunación completo contra la covid-19, vacunado en el Policlínico “Vicente Fernández Mejía”, localizado en Santa Rosa, Copán, durante marzo y mayo. Se analizaron variables sociodemográficas y factores de riesgo.The covid-19 pandemic implies a shocking crisis for contemporary times in public health. Which has been mitigated by emerging studies from the scientific community. To generate collaborations, the ACT accelerator and its laboratory advances on vaccines sta nding out. Consequently, the scarcity of valuable information on pharmacovigilance related to the different sociodemographic factors. Therefore, it generates a possibility to create educational strategies on vaccination processes that aim at collective exp ansion in a systematic and controlled way. Objective : To establish the adverse reactions and side effects raised in the health personnel to generate strategies for a more effective vaccination. Methodology: descriptive observational study was carried out A , a series of cases in a sample of health personnel over 18 years of age, with complete vaccination scheme against SARS COV2, vaccinated at the “Vicente Fernández Mejía ” Polyclinic, located in the municipality of Santa Rosa, Copán, during the months of Ma rch and May. Sociodemographic variables and risk factors were analyzed. Results: 65% of the participants presented adverse reactions or side effects after vaccination against covid-19 from the manufacturer Astra predominantly female. The main ones Zeneca, were pain at the puncture site, fatigue, fever, headache and myoarthralgia. Which predominated in the first dose.