The purpose of this paper is to establish the variables that explain the behavior of trademark applications in Colombia between 2012 and 2016. For the analysis, a fixed effects model with robust panel errors was used, for which a determination coefficient of 99% was obtained. From these, it was possible to establish that the number of patent applications, the number of industrial design applications, the number of establishments, professional technical and technological salaries of permanent production or indefinite term contracts, departmental GDP, national investment in administration and other support activities, sales of companies in the country and advertising expenditures are significant to explain the number of trademark applications.