Artigo de Periódico
Old drawback on azlactone formation revealed by a combination of theoretical and experimental studies
Autor
Castro, Pedro P. de
Batista, Gabriel M. F.
Pinheiro, Danielle Lobo Justo
Santos, Hélio Ferreira dos
Amarante, Giovanni Wilson
Institución
Resumen
New insights into the formation of azlactone heterocycles bearing different substituents are hereby presented. The sum of both kinetic and thermodynamic factors contributes for the formation of 2-alkyl or 2-aryl substituted azlactones, while the cyclization of 2-alcoxy azlactones is less favored. These results are in perfect accordance with experimental observations obtained by infrared (IR) and electrospray ionization mass spectrometry (ESI(+)-MS) of the crude reaction mixture. -