Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability

DISTRIBUIÇÃO EPIDEMIOLÓGICA E PERFIL EVOLUTIVO DO VÍRUS MAYARO NAS AMÉRICAS: UMA ATUALIZAÇÃO SOBRE A VARIABILIDADE DO GENOMA

dc.contributorFerreira, Giulia Magalhães
dc.contributorhttp://lattes.cnpq.br/6522135001572733
dc.contributorJardim, Ana Carolina Gomes
dc.contributorhttp://lattes.cnpq.br/7960921685798643
dc.contributorJardim, Ana Carolina Gomes
dc.contributorhttp://lattes.cnpq.br/7960921685798643
dc.contributorCosta, Larissa Catharina
dc.contributorhttp://lattes.cnpq.br/2127725221876097
dc.contributorSouza, William Marciel de
dc.contributorhttp://lattes.cnpq.br/7191168464519008
dc.creatorMarinho, Mikaela dos Santos
dc.creatorFerreira, Giulia Magalhães
dc.creatorSantos, Igor Andrade
dc.creatorGrosche, Victoria Riquena
dc.creatorJardim, Ana Carolina Gomes
dc.date2022-07-28T17:47:04Z
dc.date2022-07-28T17:47:04Z
dc.date2022-06-10
dc.date.accessioned2023-09-28T20:16:17Z
dc.date.available2023-09-28T20:16:17Z
dc.identifierMARINHO, Mikaela dos Santos. Epidemiological distribution and evolutionary profile of Mayaro virus in the Americas: an update into genome variability, 2022. 32 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2022.
dc.identifierhttps://repositorio.ufu.br/handle/123456789/35324
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9046676
dc.descriptionTrabalho de Conclusão de Curso (Graduação)
dc.descriptionMayaro virus (MAYV) is the etiologic agent of Mayaro Fever, a disease characterized by dengue-like symptoms and arthralgias that can progress to a chronic condition. MAYV is phylogenetically classified into the genotypes D (widely dispersed), L (limited), and N (new), being the D the most common. Additionally, a new genotype was generated by a recombination event between L and D, resulting in the genotype L/D. There are limited epidemiological and evolutionary studies on MAYV, resulting in the difficulty in tracking the emerging potential of this virus. In this context, here we investigated the MAYV genomic variations in sequences from different regions of America, and characterized the phylogenetic relationship among virus strains. Through the analysis of 40 complete genome sequences of MAYV from the GenBank database, uploaded in South, Central, and North American Countries, the phylogenetic tree was reconstructed, showing that sequences grouped according to the genotypes L, D, and L/D. Sequences characterized as genotype D were closely related to sequences from their respective countries, suggesting that isolates may had originated from circulating lineages in the respective countries. In addition, an unidentified sequence from the United States of America grouped with the genotype D, suggesting the insertion of this genotype in the country. Furthermore, our data demonstrated that a sequence previously characterized as genotype L grouped with isolates of genotype L/D, and presented an insertion of nucleotides into the nsP3, positioned identically to the genotype L/D. These results were also corroborated by our recombination analysis, which also identified this isolate as L/D hybrid. The analysis of amino acid mutations among sequences indicated positive and negative selective pressure sites, suggesting adaptability of viral fitness. These results provide information on the epidemiological distribution and evolutionary profile of MAYV, contributing to a better understanding of genotypes circulating in the Americas, as well as the potential viral changes that may contribute to the emergence of mutation of interest or new viral genotypes.
dc.description2023-06-10
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidade Federal de Uberlândia
dc.publisherBrasil
dc.publisherBiomedicina
dc.rightsAcesso Embargado
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.subjectArboviruses
dc.subjectArbovírus
dc.subjectBioinformatics
dc.subjectBioinformática
dc.subjectGenomic variability
dc.subjectVariabilidade genômica
dc.subjectMayaro virus
dc.subjectVírus mayaro
dc.subjectMayaro fever
dc.subjectFebre do mayaro
dc.subjectCNPQ::CIENCIAS BIOLOGICAS
dc.subjectCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
dc.subjectCNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOS
dc.titleEpidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
dc.titleDISTRIBUIÇÃO EPIDEMIOLÓGICA E PERFIL EVOLUTIVO DO VÍRUS MAYARO NAS AMÉRICAS: UMA ATUALIZAÇÃO SOBRE A VARIABILIDADE DO GENOMA
dc.typeTrabalho de Conclusão de Curso


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