Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats

dc.creatorYamazaki, Ricardo K.
dc.creatorBrito, Gleisson A. P.
dc.creatorCoelho, Isabela
dc.creatorPequitto, Danielle C. T.
dc.creatorYamaguchi, Adriana A.
dc.creatorBorghetti, Gina
dc.creatorSchiessel, Dalton Luiz
dc.creatorKryczyk, Marcelo
dc.creatorMachado, Juliano
dc.creatorRocha, Ricelli E. R.
dc.creatorAikawa, Julia
dc.creatorIagher, Fabiola
dc.creatorNaliwaiko, Katya
dc.creatorTanhoffer, Ricardo A.
dc.creatorNunes, Everson A.
dc.creatorFernandes, Luiz Claudio
dc.date2019-11-08T19:09:27Z
dc.date2019-11-08T19:09:27Z
dc.date2011
dc.date.accessioned2023-09-28T20:08:07Z
dc.date.available2023-09-28T20:08:07Z
dc.identifierYAMAZAKI, R. K. et al. Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats. Lipids in Health and Disease, [S.l.], v. 10, 2011.
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/37591
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9045286
dc.descriptionBackground: Obesity is commonly associated with diabetes, cardiovascular diseases and cancer. The purpose of this study was to determinate the effect of a lower dose of fish oil supplementation on insulin sensitivity, lipid profile, and muscle metabolism in obese rats. Methods: Monosodium glutamate (MSG) (4 mg/g body weight) was injected in neonatal Wistar male rats. Threemonth-old rats were divided in normal-weight control group (C), coconut fat-treated normal weight group (CO), fish oil-treated normal weight group (FO), obese control group (Ob), coconut fat-treated obese group (ObCO) and fish oil-treated obese group (ObFO). Obese insulin-resistant rats were supplemented with fish oil or coconut fat (1 g/kg/day) for 4 weeks. Insulin sensitivity, fasting blood biochemicals parameters, and skeletal muscle glucose metabolism were analyzed. Results: Obese animals (Ob) presented higher Index Lee and 2.5 fold epididymal and retroperitoneal adipose tissue than C. Insulin sensitivity test (Kitt) showed that fish oil supplementation was able to maintain insulin sensitivity of obese rats (ObFO) similar to C. There were no changes in glucose and HDL-cholesterol levels amongst groups. Yet, ObFO revealed lower levels of total cholesterol (TC; 30%) and triacylglycerol (TG; 33%) compared to Ob. Finally, since exposed to insulin, ObFO skeletal muscle revealed an increase of 10% in lactate production, 38% in glycogen synthesis and 39% in oxidation of glucose compared to Ob. Conclusions: Low dose of fish oil supplementation (1 g/kg/day) was able to reduce TC and TG levels, in addition to improved systemic and muscle insulin sensitivity. These results lend credence to the benefits of n-3 fatty acids upon the deleterious effects of insulin resistance mechanisms.
dc.formatapplication/pdf
dc.languageen_US
dc.rightsAttribution 4.0 International
dc.rightsacesso aberto
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.sourceLipids in Health and Disease
dc.titleLow fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats
dc.typeArtigo


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