Artigo
Development of an electrochemical sensor modified with dealuminated zeolite with citric acid for hydroxyzine determination by BIA-Amperometry
Registration in:
FELIX, F. da S. et al. Development of an electrochemical sensor modified with dealuminated zeolite with citric acid for hydroxyzine determination by BIA-Amperometry. Brazilian Journal of Analytical Chemistry, [S.l.], v. 10, n. 40, p. 65-75, 2023.
Author
Felix, Fabiana da Silva
Bazzana, Matheus Julien Ferreira
Assis, Letícia Cristina
Mansur, Bethânia Leite
Vieira, Sara Silveira
Magriotis, Zuy Maria
Okumura, Leonardo Luiz
Saczk, Adelir Aparecida
Institutions
Abstract
An electrochemical sensor modified with
zeolite dealuminated with citric acid was
developed for the determination of
hydroxyzine in pharmaceutical products
during BIA-amperometry experiments. The
modified electrochemical sensor was
prepared by mixing powdered graphite with
zeolite treated with citric acid homogenized
with hexane and mineral oil (60:20:20%
w/w/w respectively). The developed sensor
showed reproducible amperometric responses in a linear range of 1.0x10-6 – 2.0x10-5 mol L-1 in +1,28 V
(vs. Ag/AgCl). The detection limit and detection limit found were 3.10x10-7 mol L-1 e 1.04x10-6 mol L-1,
respectively. The method developed by BIA-amperometry was applied for the determination of the
analyte in tablets and commercial syrups and the results found agreement with the nominal values of the
commercial samples.