Background. Obesity is considered a low-grade inflammatory state and has been associated with increased acute hase roteins as well as changes in serum fatty acids. Few studies have assessed associations between acute hase roteins and serum fatty acids in morbidly obese atients. Objective. To investigate the relationshi between acute hase roteins (C-Reactive rotein, Orosomucoid, and Albumin) and serum fatty acids in morbidly obese atients. Methods. Twenty-two morbidly obese atients were enrolled in this study. Biochemical and clinical data were obtained before bariatric surgery, and fatty acids measured in reoerative serum. Results. Orosomucoid was negatively correlated with lauric acid (p = 0.027) and eicosaentaenoic acid (EA) (p = 0.037) and ositively with arachidonic acid (AA) (p = 0.035), AA/EA ratio (p = 0.005), and n-6/n-3 olyunsaturated fatty acids ratio (p = 0.035). C-Reactive rotein (CR) was negatively correlated with lauric acid (p = 0.048), and both CR and CR/Albumin ratio were negatively correlated with margaric acid (p = 0.010, p = 0.008, res.). Albumin was ositively correlated with EA (p = 0.027) and margaric acid (p = 0.008). Other correlations were not statistically significant. Conclusion. Our findings suggest that serum fatty acids are linked to acute hase roteins in morbidly obese atients.