JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region

dc.creatorVALLINOTO, Izaura Maria Vieira Cayres
dc.creatorVALLINOTO, Antonio Carlos Rosário
dc.creatorPENA, Giselle Priscila dos Anjos
dc.creatorAZEVEDO, Vânia Nakauth
dc.creatorMACHADO, Luiz Fernando Almeida
dc.creatorISHAK, Marluísa de Oliveira Guimarães
dc.creatorISHAK, Ricardo
dc.date2019-05-29T18:10:29Z
dc.date2019-05-29T18:10:29Z
dc.date2016-08
dc.date.accessioned2023-09-28T15:55:40Z
dc.date.available2023-09-28T15:55:40Z
dc.identifierVALLINOTO, Isaura Maria Vieira Cayres et al. JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region. Brazilian Journal of infectious Diseases, Salvador, v. 24, n. 4, p. 360-364, jul./ago. 2016. DOI: http://dx.doi.org/10.1016/j.bjid.2016.05.005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/11225. Acesso em:.
dc.identifier1678-4391
dc.identifierhttp://repositorio.ufpa.br/jspui/handle/2011/11225
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2016.05.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9023739
dc.descriptionJC virus (JCV) is a member of the Polyomaviridae family and is associated with a severe disease known as progressive multifocal leukoencephalopathy, PML, which is progressively increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease.Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215 bp) and IG (610 bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected in 1.5% of samples of the HIV-1 infected subjects. Apparently, there was no significant difference between mono- (HIV-1 only) and co-infected (HIV-1 / JCV) subjects regarding their TCD4 + / TCD8 + lymphocyte counts or HIV-1 viral plasma load. Self admitted seizures, hearing and visual loses were not significantly different between the two groups.
dc.descriptionCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.descriptionUNESCO - Organização das Nações Unidas para a Educação, a Ciência e a Cultura
dc.descriptionUFPA - Universidade Federal do Pará
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedade Brasileira de Infectologia
dc.publisherBrasil
dc.publisherSBI
dc.relationBrazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.sourcehttp://ref.scielo.org/647g4c
dc.subjectJCV
dc.subjectHIV-1
dc.subjectCo-infection
dc.subjectBrazilian Amazon region
dc.titleJC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region
dc.typeArtigo de Periódico


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