Artigo de Periódico
CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks
Registro en:
1471-2164
10.1186/s12864-015-1631-0
Autor
ABREU, Vinicius Augusto Carvalho de
ALMEIDA, Sintia Silva de
TIWARI, Sandeep
HASSAN, Syed Shah
MARIANO, Diego César Batista
SILVA, Artur Luiz da Costa da
BAUMBACH, Jan
AZEVEDO, Vasco Ariston de Carvalho
RÖTTGER, Richard
Institución
Resumen
Background: Organisms utilize a multitude of mechanisms for responding to changing environmental conditions,
maintaining their functional homeostasis and to overcome stress situations. One of the most important mechanisms is
transcriptional gene regulation. In-depth study of the transcriptional gene regulatory network can lead to various
practical applications, creating a greater understanding of how organisms control their cellular behavior.
Description: In this work, we present a new database, CMRegNet for the gene regulatory networks of Corynebacterium
glutamicum ATCC 13032 and Mycobacterium tuberculosis H37Rv. We furthermore transferred the known networks of
these model organisms to 18 other non-model but phylogenetically close species (target organisms) of the CMNR
group. In comparison to other network transfers, for the first time we utilized two model organisms resulting into a
more diverse and complete network of the target organisms.
Conclusion: CMRegNet provides easy access to a total of 3,103 known regulations in C. glutamicum ATCC 13032 and
M. tuberculosis H37Rv and to 38,940 evolutionary conserved interactions for 18 non-model species of the CMNR group.
This makes CMRegNet to date the most comprehensive database of regulatory interactions of CMNR bacteria. The
content of CMRegNet is publicly available online via a web interface found at http://lgcm.icb.ufmg.br/cmregnet. MMCI - Cluster of Excellence for Multimodal Computing and Interaction SILVA, A. L. C. Universidade Federal do Pará