Photodynamic therapy mediated by a red LED and methylene blue inactivates resistant leishmania amazonensis

dc.creatorCABRAL, FERNANDA V.
dc.creatorYOSHIMURA, TANIA M.
dc.creatorSILVA, DANIELA de F.T. da
dc.creatorCORTEZ, MAURO
dc.creatorRIBEIRO, MARTHA S.
dc.date2023
dc.date2023-06-30T13:11:35Z
dc.date2023-06-30T13:11:35Z
dc.date.accessioned2023-09-28T14:26:13Z
dc.date.available2023-09-28T14:26:13Z
dc.identifier1084-7529
dc.identifierhttp://repositorio.ipen.br/handle/123456789/34107
dc.identifier5
dc.identifier40
dc.identifier10.1364/JOSAA.482314
dc.identifier0000-0002-4203-1134
dc.identifier31.5
dc.identifier53
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9004315
dc.descriptionCutaneous leishmaniasis is a neglected parasitic disease that leads to destructive lesions. The emergence of drug resistance has been a global concern over the past years. Photodynamic therapy (PDT) mediated by a red LED and methylene blue (MB) involves the overproduction of oxidative stress, which oxidizes several cellular biomolecules and prevents the selection of resistant strains. Herein, we investigated the potential of PDT mediated by MB against wild-type and miltefosine-resistant strains of Leishmania amazonensis. As a result, both strains were susceptible to PDT, thus encouraging us to seek the best conditions to overcome the drug resistance problem in cutaneous leishmaniasis.
dc.descriptionConselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)
dc.descriptionCNPq: 440228/2021-2; 465763/2014-6
dc.format996-1005
dc.relationJournal of the Optical Society of America A
dc.rightsopenAccess
dc.subjectprotozoa
dc.subjectparasitic diseases
dc.subjectskin diseases
dc.subjectphotodynamic therapy
dc.subjectmethylene blue
dc.subjectlight emitting diodes
dc.titlePhotodynamic therapy mediated by a red LED and methylene blue inactivates resistant leishmania amazonensis
dc.typeArtigo de peri??dico
dc.coverageI


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