Head-to-head comparison between 68Ga-PSMA and 18F-FDG-PET/CT in lymphomas

dc.creatorSOUZA, STEPHAN P.M. de
dc.creatorTOBAR, NATALIA
dc.creatorFRASSON, FERNANDA
dc.creatorPERINI, EFRAIN A.
dc.creatorSOUZA, CARMINO A. de
dc.creatorDELAMAIN, MARCIA T.
dc.creatorRAMOS, CELSO D.
dc.date2021
dc.date2022-03-17T13:34:11Z
dc.date2022-03-17T13:34:11Z
dc.date.accessioned2023-09-28T14:21:25Z
dc.date.available2023-09-28T14:21:25Z
dc.identifier0143-3636
dc.identifierhttp://repositorio.ipen.br/handle/123456789/32810
dc.identifier12
dc.identifier42
dc.identifier10.1097/MNM.0000000000001465
dc.identifier15.81
dc.identifier53.00
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9003029
dc.descriptionPurpose: Isolated case reports mention the uptake of radiolabeled PSMA in lymphoma. However, it is not clear if the intensity of 68Ga-PSMA expression varies among different histological subtypes or if it correlates with 18F-FDG uptake. This study compared both tracers in patients with diverse lymphoma subtypes. Methods: Ten patients with biopsy-proven-lymphoma underwent 18F-FDG and 68Ga-PSMA-PET/CT (maximum time interval: 6 days). Lymphoma subtypes included Hodgkin???s lymphoma (HL, three patients) and aggressive and indolent non-Hodgkin???s lymphoma (NHL, seven patients). The intensity of PSMA uptake was classified visually as low, intermediate, or high, using blood pool, liver and parotid gland uptake as references. Maximum standardized-uptake value (SUVmax) of each affected site was measured in both sets of images. Results: FDG detected 59/59 involved sites in 10 patients and PSMA 47/59 sites in nine patients. PSMA uptake was generally low, regardless of the intensity of FDG uptake, but it was classified as intermediate in two patients. The median SUVmax varied from 2.0 (2.0???8.2) to 30.9 for FDG and from 1.7 (1.7???1.7) to 4.4 for PSMA, P < 0.0001. The primary lesion of one patient had a marked intralesional mismatch uptake pattern of the tracers, with areas of higher PSMA expression than FDG uptake, and vice-versa. A brain lesion was more easily identified with PSMA than with FDG images. Conclusion: HL and several NHL subtypes may present PSMA uptake. The intensity of PSMA expression is generally lower than that of FDG uptake and seems to present less variation among the different histological subtypes of lymphomas.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionCoordena????o de Aperfei??oamento de Pessoal de N??vel Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)
dc.descriptionFAPESP: 09/54065-0; 18/00654-4
dc.descriptionCAPES: 001
dc.descriptionCNPq: 311841/2018-0
dc.format1355-1360
dc.relationNuclear Medicine Communications
dc.rightsopenAccess
dc.subjectdiagnosis
dc.subjectneoplasms
dc.subjectprostate
dc.subjectantigens
dc.subjectgallium 68
dc.subjectlymphomas
dc.subjecthodgkins disease
dc.titleHead-to-head comparison between 68Ga-PSMA and 18F-FDG-PET/CT in lymphomas
dc.typeArtigo de peri??dico
dc.coverageI


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