Herpes simplex (HSV) is commonly encountered in the dentistry practice disappearing after 10 to 14 days. Recently alternative treatments have been introduced, among those laser therapy. The aim of this study is to evaluate the efficacy of laser therapy in patients with perioral herpes simplex infection. A 32 years old female was treated with high-intensity laser therapy (HILT) in vesicle phase using a Nd:YAG laser, l= 1064 nm, P= 1,5 W, f= 15 Hz on days 1 and 2 to drainage the vesicles. Low-intensity laser therapy (LILT) was applied on the affected area in the 3 consecutive days with a GaAlAs laser, l= 830 nm, D= 5 J/cm2. On the other hand, a 7 years male patient, which presented the vesiculo-ulcerative stage, only LILT (l= 660 nm, D= 4 J/cm2) was carried out. For both cases, it was observed that the course of the infection was quicker than the normal. Seven days after treatment beginning the lesions were healed. These findings suggest that LILT associated or not to HILT is a efficient and promising treatment for HSV. Further larger studies aiming at confirming these data and investigating the LILT mechanisms of action should be performed.