Knee radiosynovectomy with 153Sm???hydroxyapatite compared to 90Y???hydroxyapatite

dc.creatorSANTOS, ALLAN O.
dc.creatorRICCIARDI, JANAINA B.S.
dc.creatorPAGNANO, RODRIGO
dc.creatorPEREIRA, LUIS F.M.
dc.creatorSAKUMA, EMERSON T.
dc.creatorMATSUDA, MARGARETH M.N.
dc.creatorBERNARDES, EMERSON S.
dc.creatorARAUJO, ELAINE B.
dc.creatorBRUNETTO, SERGIO Q.
dc.creatorTAKAHASHI, MARIA E.S.
dc.creatorBRUNETTO, EDNA M.
dc.creatorZULLI, ROBERTO
dc.creatorOZELO, MARGARETH C.
dc.creatorETCHEBEHERE, ELBA C.S.C.
dc.date2021
dc.date2021-04-16T18:38:41Z
dc.date2021-04-16T18:38:41Z
dc.date.accessioned2023-09-28T14:18:26Z
dc.date.available2023-09-28T14:18:26Z
dc.identifier0914-7187
dc.identifierhttp://repositorio.ipen.br/handle/123456789/31983
dc.identifier2
dc.identifier35
dc.identifier10.1007/s12149-020-01557-5
dc.identifier0000-0002-0029-7313
dc.identifier0000-0003-4455-3486
dc.identifier28.31
dc.identifier58.00
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9002206
dc.descriptionIntroduction Radiosynovectomy (RS) with 90Y-hydroxyapatite (90Y-HyA) aims to control knee hemarthrosis in hemophiliac patients to prevent secondary arthropathy. However, knee RS using 153Sm-hydroxyapatite (153Sm-HyA) is considered less suitable due to the lower average soft tissue range and energy of 153Sm for large joints, such as the knees. Purpose The objective of this investigation was to assess the efficacy and safety of knee RS with 153Sm-HyA, compared to 90Y-HyA. Methods Forty patients were prospectively assigned to undergo knee RS with 153Sm-HyA (n = 19) or with 90Y-HyA (n = 21). The frequency of hemarthrosis episodes before and after treatment were compared. Results After six months of knee RS, 153Sm-HyA and 90Y-HyA promoted a similar reduction of hemarthrosis episodes (50% and 66.7%, respectively). However, after 12 months of knee RS, the reduction of hemarthrosis episodes was significantly (p = 0.037) higher using 153Sm-HyA (87.5%) compared to 90Y-HyA (50.0%). This discrepancy was more pronounced (p = 0.002) for 153Sm-HyA compared to 90Y-HyA in adults/adolescents. Conclusion Knee radiosynovectomy with 153Sm-HyA is safe, reduces hemarthrosis episodes after 12 months of treatments, especially in adults/adolescents and even with grades III/IV arthropathy, similar to 90Y-HyA. 90Y-HyA seems to promote better hemarthrosis control in small children.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionFAPESP: 13/05255-7
dc.format232-240
dc.relationAnnals of Nuclear Medicine
dc.rightsopenAccess
dc.subjectapatites
dc.subjecthemophilia
dc.subjecthydroxides
dc.subjectinflammation
dc.subjectrheumatic diseases
dc.subjecttherapy
dc.subjectsamarium 153
dc.titleKnee radiosynovectomy with 153Sm???hydroxyapatite compared to 90Y???hydroxyapatite
dc.typeArtigo de peri??dico
dc.coverageI


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