Artigo de peri??dico
Quantification of retinal capillary nonperfusion in diabetics using wide-field optical coherence tomography angiography
Registro en:
0275-004X
3
40
10.1097/IAE.0000000000002403
0000-0002-5018-9126
84.68
92.00
Autor
ALIBHAI, A.Y.
PRETTO, LUCAS R. de
MOULT, ERIC M.
OR, CHRIS
ARYA, MALVIKA
MCGOWAN, MITCHELL
CARRASCO-ZEVALLOS, OSCAR
LEE, BYUNGKUN
CHEN, SIYU
BAUMAL, CAROLINE R.
WITKIN, ANDRE J.
REICHEL, ELIAS
FREITAS, ANDERSON Z. de
DUKER, JAY S.
FUJIMOTO, JAMES G.
WAHEED, NADIA K.
Resumen
Purpose: To combine advances in high-speed, wide-field optical coherence tomography
angiography (OCTA) with image processing methods for semiautomatic quantitative
analysis of capillary nonperfusion in patients with diabetic retinopathy (DR).
Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with
different degrees of retinopathy, were prospectively recruited for volumetric swept-source
OCTA imaging using 12 mm ?? 12 mm fields centered at the fovea. A custom, semiautomatic
software algorithm was used to quantify areas of capillary nonperfusion.
Results: The mean percentage of nonperfused area was 0.1% (95% confidence interval:
0.0???0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2???3.7) in the nonproliferative
DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval:
5.0???14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in
a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to
eyes with proliferative DR.
Conclusion: Capillary nonperfusion area in the posterior retina increases with increasing
DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion
on wide-field OCTA may be useful for early detection and monitoring of disease in
patients with diabetes and DR. Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP) FAPESP: 16/17342-0; 15/15775-3