This work describes multiphysics analyses conducted to investigate the effect of geometric deviations and materials properties on flow-induced deflections of fuel plates. The analyzed configuration consists of two fuel plates and each one of them is bounded by two fluid channels. The fluid-dynamic forces acting on the plates are calculated using a Computational Fluid Dynamics model and the structural response is determined by means of a Finite Element Analysis model. Both models are coupled using the two-way fluid-structure interaction approach. The results show that manufacturing deviations from the nominal conditions and the increment of the system temperature lead to reduce the critical fluid velocity of the assembly.Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior (CAPES)CAPES: 001